Hi, Brandon,
I have trouble running ISE on 16.04.1 LTS, ISE GUI opens but stuck at creating new project forever.
I had been working with ISE 14.7 on 14.04 for years without any issue, and didn't even need to do # chown -R <username>: /opt/Xilinx
What I might be missing?
Just tested, I can get 16.04 working on a newly created virtualbox, will retest 16.04.1
Please comment,