Hi Felix, Jack, thanks a lot for your quick answers, appreciate it! I followed the instructions from Felix and removed the driver using the CDM Uninstaller. This laptop is used in combination with different lab hardware and therefore had some FTDI drivers installed. After reboot and reinstalling DesignLab (and driver) and connecting the Papilio Duo board it shows that no driver can be installed for Papilio Duo. I'm currently installing ISE and DesignLab on a second laptop (both laptops running Windows7 64bit and I have a admin account). This laptop has been used with the logicsniffer. I will update this post once I have results from the second laptop. Update: The FPGA part is working perfectly fine when using the 2nd laptop. (Haven't tested the AVR but don't expect any issues there). Solution: In my case it seem to be messed up FTDI drivers. I'll try again to uninstall all of them and then reinstall the Papilio DUO driver. Thanks again for the quick help! Martin Note: This board has not been replaced, it's the original board that has been delivered end of March this year.